| EABA | 2003 | Blacksburg Tactical Research Center | United States |
| Earthdawn | 1993 | — | United States |
| Earthdawn (1st edition) | 1993 | FASA Corporation | — |
| Earthdawn (2nd edition) | 2001 | Living Room Games | — |
| Earthdawn (3rd edition) | 2009 | RedBrick Limited | — |
| Earthdawn (4th edition) | 2015 | FASA Corporation | — |
| Earthdawn (Age of Legend edition) | 2016 | — | — |
| Earthdawn (Classic edition) | 2005 | RedBrick Limited | — |
| Earthdawn (Revised 3rd edition) | 2012 | RedBrick Limited | — |
| Eat the Reich | 2023 | — | — |
| Eclipse Phase | 23 August 2009 | Posthuman Studios | United States |
| Ehdrigor | 2012 | — | — |
| El-Hazard Role-Playing Game | 2001 | Guardians of Order | Canada |
| Eldritch Role-Playing System | 2008 | — | — |
| Eldritch Wizardry | 1976 | TSR | United States |
| Electric Bastionland | — | Bastionland Press | — |
| Elegant Role-Playing | 2002 | self-published work | — |
| Element Masters | 1983 | — | — |
| Elfquest | 1984 | Chaosium | United States |
| Elfs | 2000 | Adept Press | United States |
| Elish | 1994 | — | Italy |
| Elric! | 1993 | Chaosium | United States |
| Empire galactique | 1984 | Robert Laffont | France |
| Empire of the Petal Throne | 1975 | TSR | United States |
| Empires & Dynasties | 1988 | Dragon Radieux | France |
| En Garde! | 1975 | Game Designers' Workshop | United States |
| Enemy Gods | 2004 | John Wick Presents | United States |
| Enforcers | 1987 | — | — |
| Engel | 2002 | — | Germany |
| Enterprise: Role Play Game in Star Trek | 1983 | — | — |
| Eon | 1996 | — | — |
| Epyllion: a Dragon Epic | 2016 | Magpie Games | United States |
| Erdor | 2000 | — | Canada |
| Espada Negra | — | — | Spain |
| Espionage! | 1983 | — | — |
| Eternal Soldier | 1986 | — | — |
| Etherscope | 2006 | Goodman Games | United States |
| EverQuest Role-Playing Game | 2002 | White Wolf Publishing | United States |
| Everway | 1995 | Wizards of the Coast | United States |
| EW-System | 2004 | Extraordinary Worlds Studio | France |
| Exalted | 2001 | White Wolf Publishing | United States |
| Exalted (1st ed.) | 2001 | White Wolf Publishing | United States |
| Exalted (2nd edition) | 2006 | — | United States |
| Exalted (3rd edition) | 2016 | Onyx Path Publishing | United States |
| Exil | 2005 | — | France |
| Exodus | 2008 | — | — |
| Expendables | 1987 | — | — |
| Extreme Vengeance | 1997 | — | — |